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THE ROLE OF SERUM ACUTE PHASE REACTANT LEVELS IN THE PREDICTION OF IMPACTED URETERAL STONE
ISMET AYDİN HAZAR, TUNCAY TAS, CEM TUGRUL GEZMİS, ERSAN ARDA, NUSRET CAN CİLESİZ, BASRİ CAKİROGLU
International Journal of Medical Biochemistry - 2019;2(3):102-106
Department of Urology, University of Health Sciences Gaziosmanpasa Taksim Training and Research Hospital, Istanbul, Turkey

Objectives: The aim of this study was to investigate the determination of ureteral stone impaction using acute phase reactants. Methods: A total of 110 patients who had a single ureteral stone treated during a single month using medical expulsive therapy of tamsulosin 0.4 mg/day, diclofenac 75 mg upon analgesic requirement, and at least 3 liters fluid per day were evaluated prospectively. The patients underwent ureteroscopy and were divided into 2 groups according to the presence or absence of impaction. The preoperative white blood cell (WBC) count, red blood cell distribution width (RDW), C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), mean platelet volume (MPV), and neutrophil-tolymphocyte ratio (NLR) in the non-impacted stone group (Group 1; n=59) and the impacted group (Group 2; n=51) were statistically compared. Results: There was no statistically significant difference in terms of age, stone diameter, body mass index, grade of hydronephrosis, or stone localization between the 2 groups. The WBC, RDW, and MPV value differences were statistically significant between the groups (p=0.035, p=0.035, and p=0.005, respectively). An MPV cut-off value of 9.55 fL was defined in Group 2 with 66% sensitivity and 62% specificity for impaction. There was no statistically significant difference between the groups in CRP, ESR, or NLR values (p=0.44, p=0.76, p=0.54, respectively). Conclusion: Evaluation of serum MPV with a cut-off value of 9.55 fL may predict ureteral stone impaction.

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