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EPICARDIAL FAT THICKNESS IS ASSOCIATED WITH RETINOPATHY IN PATIENTS WITH NEWLY DIAGNOSED HYPERTENSION
SAVAS OZER, BURCU YUCEKUL, AHMET SEYDA YİLMAZ, ALİ GOKHAN OZYİLDİZ, MUSTAFA KİNİK, OGUZHAN EKREM TURAN, MEHMET GOKHAN ASLAN, MUSTAFA CETİN
İstanbul Kuzey Klinikleri Dergisi - 2021;8(4):365-370
Department of Cardiology, Recep Tayyip Erdogan University Training and Research Hospital, Rize, Turkey

OBJECTIVE: Hypertensive retinopathy develops based on endothelial dysfunction, inflammation, and atherosclerosis. Epicardial fat secretes various cytokines associated with endothelial dysfunction, oxidative stress, inflammation, and atherosclerosis. We aimed to evaluate whether epicardial adipose tissue (EAT) thickness is a marker for retinopathy in newly diagnosed hypertensive patients. METHODS: A total of 73 newly diagnosed hypertension (HT) patients were included in the study. Transthoracic echocardiography (TTE) was used to measure EAT thickness. To evaluate the presence of retinopathy in HT patients, hypertensive retinopathy staging was performed by ophthalmologists, according to Scheie classification. Results: Retinopathy was detected in 27 (37.0%) of 73 patients. EAT thickness in HT patients with retinopathy was higher than the group without retinopathy (5.07±1.45 mm vs. 4.19±1.20 mm, p=0.007). Low-density lipoprotein cholesterol (LDL-C) levels in HT patients with retinopathy were higher than the group without retinopathy (162.4±41.2 mg/dl vs. 138.1±35.6 mg/dl, p=0.010). As a result of the regression analysis, LDL-C (OR=1.016, 95% CI 1.001–1.031, p=0.043) and EAT thickness (OR=1.674, 95% CI 1.069–2.626, p=0.043) were the independent predictors of retinopathy. Conclusion: Increased EAT thickness is associated with the presence of retinopathy in hypertensive patients.

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