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PROGNOSTIC FACTORS OF ENDOMETRIAL CANCER IN ELDERLY PATIENT GROUP AND THEIR EFFECTS ON SURVIVAL
SONGUL ALEMDAROGLU, GULSEN DOGAN DURDAG, SAFAK YİLMAZ BARAN, SEDA YUKSEL SİMSEK, SELCUK YETKİNEL, DİDEM ALKAS YAGİNC, OZAN CEM GULER, HUSNU CELİK
İstanbul Kuzey Klinikleri Dergisi - 2021;8(4):345-353
Department of Obstetrics and Gynecology, Baskent University Faculty of Medicine, Adana Dr. Tugut Noyan Training and Medical Research Center, Adana, Turkey

OBJECTIVE: The objective of the study was to investigate the prognostic factors of the elderly group and their effects on survival by examining the histopathological features, surgical treatment protocols, and treatment modalities of patients diagnosed with endometrial cancer (EC). METHODS: The records of 397 EC patients who completed their treatment and follow-up at a single center between 2012 and 2019 were evaluated retrospectively. The patients were evaluated in two groups as <70 years old (n: 301; 75.8%) and >70 years old (n: 96; 24.2%). Following the evaluation of histopathological features and treatment protocols, independent risk factors influencing survival were investigated with the Cox regression model. Results: The incidence of non-endometrioid histology (16.3% vs. 32.3%, p: 0.001), high-grade tumors (50.5% vs. 69.8%; p: 0.001), and >50 myometrial invasion (19.6% vs. 36.5%, p: 0.003) in the >70 age group was more frequent than that in the <70 age group. The independent risk factors on overall survival in the >70 age group were determined as non-endometrioid histology (HR: 5.9; 95% CI: 1.4– 24.7) and lymph node metastasis (HR: 6.4; 95% CI: 1.6–25.0). In the <70 age group, non-endometrioid histology (HR: 11.3; 95% CI: 4.0–32.0) was identified as the only independent risk factor affecting 5-year survival. Conclusion: EC, with non-endometrioid histology, which is observed at a higher rate in elderly patients despite equal surgery and adjuvant therapy, is the primary factor that affects survival.

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