Mario LEPORACE, Ferdinando CALABRIA, Antonio LANZILLOTTA
Endocrinology Research and Practice - 2026;30(2):127-129
The use of radioactive 131I (Iodine) to treat well-differentiated thyroid carcinomas is a well-established practice. However, in some cases, 131I may be retained in the gallbladder, leading to false-positive results in the detection of thyroid cancer spread. Unexplained radioiodine uptake in the gallbladder can occur, especially in patients with underlying biliary disease or gallbladder abnormalities. It is important to use single photon emission computed tomography (SPECT), computed tomography (CT), SPECT/CT, and ultrasound (US) findings to confirm that this uptake is not related to cancer.
