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A NEW MOUSE MODEL OF WHOLE PANCREAS TRANSPLANT WITH GRAFT BLOOD THROUGH THE PORTAL VEIN

HUİZHONG SHİ, SHURUİ WU, ZİKUN RAN, HAOWEN TANG, QİRU XİONG

Experimental and Clinical Transplantation - 2024;22(1):52-62

Faculty of Hepato-Pancreato-Biliary Surgery, Chinese PLA General Hospital, Beijing, China

 

Objectives: Pancreas transplant is currently the most effective method for maintaining physiological blood sugar levels and reversing small blood vessel injuries. Our team developed a model of whole pancreas transplant based on microsurgical techniques following the investigation of more than 300 mice. Materials and Methods: A mouse pancreatic transplant model is required to investigate the pathophysiological process of pancreas transplant and pancreatic preservation technologies. Recently, the segment-neck pancreas transplant has been the most utilized mouse pancreatic transplant model. The innovative mouse pancreatic transplant model that we developed in this study uses the whole pancreas and returns heart blood flow into the liver via the portal vein. Results: With our mouse pancreatic transplant model, the survival rate of mice after transplant was >80%, and the success rate of pancreatic transplant was >90%. Conclusions: The segment-neck and the whole pancreas model can guarantee that the transplanted pancreas functions effectively, and both have excellent postoperative outcomes, survival rates and pancreatic active rates.