Hüseyin Anıl KORKMAZ
Turkish Archives of Pediatrics - 2026;61(2):175-176
Van Wyk Grumbach Syndromes (VWGS) are very rare, with fewer than 100 cases reported in the literature. The rarity of this condition is due to high thyroid-stimulating hormone (TSH) levels stimulating a follicle-stimulating hormone (FSH) effect via the FSH receptor. Both TSH and FSH hormones possess a glycoprotein structure. They exhibit intricate interrelationships within the hypothalamic-pituitary-ovarian axis, particularly in the context of negative feedback loops. Few data exist regarding cases of VWGS mimicking central precocious puberty in children; consequently, it is unclear if these cases would benefit from thyroid hormone replacement. Herein, the aim was to present a case in which a patient with peripheral precocious puberty may benefit from thyroid hormone replacement.
