Shabnam Shahab, Cem Selim, Rafiye Çiftçiler
Journal of Current Hematology & Oncology Research - 2025;3(4):103-105
Primary bone lymphoma (PBL) is a rare subtype of non-Hodgkin lymphoma, comprising a small proportion of primary bone malignancies and extranodal lymphomas. It typically presents with nonspecific symptoms such as localized bone pain, leading to delayed diagnosis. In this case report, we present a 39-year-old male with no prior comorbidities who applied with right hip pain and was ultimately diagnosed with diffuse large B-cell lymphoma of the femur, germinal center phenotype. Radiological findings revealed a large intramedullary lesion with cortical destruction, and diagnosis was confirmed histopathologically. Despite initial treatment with R-CHOP chemotherapy, the disease showed partial resistance, necessitating second-line R-ICE therapy and localized radiotherapy. Post-treatment imaging demonstrated regression of destructive findings, and PET- CT showed minimal residual activity. The patient has remained symptom-free and under observation since 2020. This case emphasizes the importance of a multidisciplinary approach, combining imaging, histopathology, and multimodal therapy in the effective management of PBL, and contributed to the growing body of evidence guiding the prognosis and therapeutic strategy of this rare entity.
