ISLAM BOULAARES, SAMİR DEROUİCHE
Journal of Microbiology and Infectious Diseases - 2024;14(4):146-157
Purpose: Antibiotics are drugs used to treat and prevent bacterial infections. The emergence of antibiotic resistance in bacterial strains is one of the most important problems facing global health care. There are several alternatives to get rid of antibiotic resistance, including nanoparticles, which is the subject of this study on how to use manganese oxide nanoparticles (MnO NPs) as antimicrobials with greater effectiveness and less resistance to them. Materials and methods: There are several physical, chemical, and biological techniques for the production of nanoparticles. However, the green synthesis of nanoparticles has been developed to improve the environment and human health safety, minimize pollution, and save expenses by using plant extracts instead of industrial chemical components to reduce metal ions. Accurate and comprehensive characterization using various physicochemical techniques is crucial for ensuring biological activity, safety, and reproducibility in the production of these MnO NPs. Results: Green synthesized MnO NPs are a promising source of new antiviral, antibacterial, and antifungal agents considering the multiplicity of its mechanism and the multiple target areas in the microbes. The MnO NPs interact directly with some biological molecules of the microbes, such as some proteins, DNA, and RNA. This reaction generates reactive oxygen species (ROS), causing damage to the membranes in the microbes. Metal nano-therapies such as MnO NPs are granted research consideration for virus, bacteria, or fungi treatment. Conclusion: The biocompatibility achieved through green synthesis of MnO NPs suggests its possible use in several types of microbe’s infections with less risk of toxicity of these new materials.
