Semih Lütfi MIRAPOĞLU, Sümeyye KOÇ, Doğan YILDIRIM, Mahmut Said DEĞERLİ, Ganime ÇOBAN, Nurcan ÜNVER, Ömer Faruk ÖZER, Kamil ŞAHİN, Ceyhan ŞAHİN, Ali ÇAY
Laparoscopic Endoscopic Surgical Science - 2025;32(4):188-196
Introduction: In laparoscopic surgery, pneumoperitoneum is created using carbon dioxide, helium, or ambient air. We aimed to investigate the effects of these gases on the organs. Materials and Methods: The experiment involved 25 male Sprague-Dawley rats aged 5-6 months, were divided into four groups. Group 1 (n=4) was the control group. Pneumoperitoneum was induced in Groups 2 (n=7), 3 (n=7), and 4 (n=7) using carbon dioxide, helium, and room air, respectively. After 2 hours, the gas was evacuated, and blood samples were collected. Blood was drawn 24 h later. The rats were euthanized, and tissue samples from the liver, pancreas, kidney, intestine, and lungs were collected for examination. Results: There were no significant differences in the severity of inflammation or intestinal effects between the groups. Adverse effects on the lungs, liver, and pancreas were greater in the carbon dioxide group. All groups showed negative effects on the kidneys, regardless of the gas type. Although laparoscopic surgery has many advantages over open surgery, the type of gas used and the increased intra-abdominal pressure can cause adverse effects. However, we believe that these effects are likely transient and should be verified through clinical experience. Conclusion: In laparoscopic surgery, the choice of insufflation gas and elevated intra-abdominal pressure may induce transient adverse effects in various organs, highlighting the need for further clinical studies to substantiate these findings.
