Ebru YUCEL, Yasar Doruk KILICASLAN, Rasim Levent KILICASLAN
Experimental and Applied Medical Science - 2026;7(2):105-123
Aim: Comparison of rapidly absorbable monofilament "Polydioxanon", non-absorbable monofilament "Polypropylene" and slowly absorbable polyfilament "Polycaprolactone" wound treatment material sutures' effects on growth factors in wound healing by an experimental design with biochemical analyses. Methods: Ankara University Ethical Council number 20.14-16-111 permission was taken and 8-12 weeks old, 150-200 gram, 72 male Wistar albino rats were randomly separated into nine groups that each had eight rats. The Sham 7th and 14th, Polypropylene 7th and 14th, Polydioxanon 7th and 14th, Polycaprolactone 7th and 14th groups, besides a Control group were formed. On 7th day of wound formation Sham 7 th, Polypropylene 7 th, Polycaprolactone 7 th, Polydioxanone 7 th groups each containing eight rats tissues' were sampled (n=32). The Sham 14th, Polypropylene 14th, Polydioxanon 14th, Polycaprolactone 14th groups that each had eight rats (n=32) and control group (n=8) were tissue sampled on 14th day (n=40). "Collagen", "FGF", "VEGF", "EGF" and "KGF" tissue levels were calculated (?n=72). "Suture construction was the stable, filament contructions and absorbability were variable parameters". Findings: Slowly absorbable "Polycaprolacton" and rapidly absorbable "Polydioxanon" treatment materials "elevated the collagen" formation. "The highest FGF" level which was "responsable for collagen formation" were detected with "Polycaprolacton" and in wound healing vascularization responsible VEGF was observed "the lowest" with "Polypropylene". Finally, "Polycaprolactone" suture "elevated KGF the most" and "improved skin healingas potent epithelisant". Conculsion: Absorbable "Polycaprolacton" and "Polydioxanon" both had "the highest collagen" level in tissues which could indicate "effectiveness of soluble treatment materials" in wound healing. "The highest FGF" responsible for "the highest collagen" formation was found with absorbable "Polycaprolacton". On 14th day absorbable "Polycaprolactone" was observed as "the prevailed epitelisant" among all groups and had "the highest KGF levels" for skin wound healing. "The lowest VEGF levels" that decelerates vascularization delaying wound healing was observed with non-absorbable "Polypropylene".
