SAİME YETİŞ, YAKUP ERATA, SABAHATTİN ALTUNYURT
Gynecology Obstetrics & Reproductive Medicine - 2005;11(2):96-98
Objective: Evaluate the effect of a single cigarette smoking on fetal and placental blood flow indexes and serum Nitric oxide (NO) levels. Study Design: 38 pregnant women between 28th and 33rd gestational weeks who smoke during pregnancy were included into this study. Doppler indexes were determined from both uterine artery, middle cerebral artery (MCA) and umbilical artery. Subjects were asked for smoking a standard 100 mm cigarette within 5 minutes after basal measurements. Doppler indexes were repeated 15 minutes after smoking. Pulse and blood pressure measurements and Plasma levels of NO metabolites were determined before and after smoking. Results were compared. Results: Mean systolic and diastolic blood pressure and pulse were higher after smoking (p<0.05). We found a significant decrease only in RI and S/D of MCA (p<0.05). Mean RI, PI and S/D ratios of uterine arteries and umbilical artery were not significantly changed after smoking of a cigarette. Plasma levels of NO metabolites were similar before and after smoking. Conclusion: Possible hemodynamic effects of smoking on fetal and uterine vessels seem not related to NO. However the hemodynamic effects of smoking on fetal and uterine vessels are not certain.
