Yavuz ÖZER, Rüveyda GÜLMEZ, Hande TURAN, Gürkan TARÇIN, Dilek Bingöl AYDIN, Olcay EVLİYAOĞLU, Oya ERCAN
Journal of Clinical Research in Pediatric Endocrinology - 2026;18(2):342-345
We report a patient with papillary thyroid carcinoma (PTC) who developed acute kidney injury (AKI) and elevated creatine kinase (CK) after thyroid hormone withdrawal (THW) prior to radioiodine therapy. A 12-year-old female patient who had undergone total thyroidectomy for PTC one year previously, presented with leg pain for the past two days. Following THW three weeks earlier, she had received 70 mCi radioiodine treatment six days before this presentation. Serum creatinine [1.53 mg/dL, normal range (NR): 0.3-1.1], aspartate aminotransferase (102 IU/L, NR: 0-40) and CK (3451 IU/L, NR: 26-174) levels were elevated. Thyrotropin level was elevated (µIU/mL, NR: 0.51-4.3), and free T4 level was decreased (0.05 ng/dL, NR: 0.98-1.63). Serum creatinine and CK levels decreased after intravenous hydration and levothyroxine treatment. In PTC cases with thyroidectomy, kidney function and CK elevation should be assessed after THW and dehydration should be prevented.
