ECE BÜYÜKSANDALYACI TUNÇ, HİDAYET ECE ARAT ÇELİK, BURCU KÖK KENDİRLİOĞLU, ESMA ÇÖREKLİ KAYMAKÇI, HATİCE BEGÜM ÇİFTÇİ, ŞEVİN DEMİR, SUAT KÜÇÜKGÖNCÜ
Medical Journal of Bakırköy - 2025;21(2):207-214
OBJECTIVE Bipolar disorder (BD) is a severe psychiatric disorder characterized by recurrent episodes of mania and depression. Studies have reported the involvement of inflammatory processes in the pathophysiology of BD. This study aims to demonstrate that certain inflammatory markers are elevated in BD patients and to highlight their potential for use in diagnosis, prognosis, and treatment monitoring. METHODS This study included 57 BD patients and 121 healthy controls (HC). All participants underwent a complete blood count. Subsequently, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI) values were calculated. The ethics committee approval for the study was obtained from Maltepe University Faculty of Medicine on January 19, 2022, number 2022/900/02. RESULTS The NLR, mean platelet volume (MPV), red cell distribution width (RDW), AISI, and SIRI values were higher in BD patients compared to HC. No significant differences were found in MLR, PLR, and SII levels between the BD and HC groups. CONCLUSION Higher NLR, MPV, RDW, AISI, and SIRI values in BD patients than HC suggest increased inflammatory processes in BD. NLR, MPV, RDW, SIRI, and AISI are believed to be involved in the pathophysiology of BD and hold potential as biomarkers for monitoring disease prognosis and treatment efficacy. To further understand the underlying mechanism of BD, additional longitudinal studies are needed to determine how BD impacts inflammatory processes.
