Murat OZER
Asthma Allergy Immunology - 2025;23(3):350-352
Drug-Induced Enterocolitis Syndrome (DIES) is an increasingly recognized but still underreported non-IgE-mediated hypersensitivity reaction, most commonly triggered by beta-lactam antibiotics. Clinically, it resembles Food Protein-Induced Enterocolitis Syndrome (FPIES), presenting with delayed gastrointestinal symptoms such as repetitive vomiting, lethargy, diarrhea, and hypotension within 1 to 4 hours after drug ingestion. However, due to the absence of specific biomarkers and the lack of standardized diagnostic criteria, diagnosing DIES remains challenging. Although its exact immunopathogenesis has not been fully elucidated, a T-cell-mediated response involving neutrophilic inflammation and cytokine release is suspected (1, 2). The limited number of reported cases has contributed to low awareness among healthcare professionals, often resulting in misdiagnosis or delayed intervention. In this report, we present a 7-year-old boy who developed DIES following oral administration of cefuroxime and describe in detail the clinical evaluation and management. To our knowledge, this is the first reported case of DIES associated with cefuroxime in the literature.
