Tahir Muhammad DISINA, Ahmed-Sherif ISA, Philemon Paul MSHELIA, Amat Abdoulie TEKANYI
The Journal of Neurobehavioral Sciences - 2026;13(2):40-48
Parkinson's disease is the most common neurodegenerative disease after Alzheimer's disease characterized by early degeneration of dopaminergic neurons in the substantia nigra pars compacta and accumulation of Lewy bodies. Parkinson's disease is associated with non-motor symptoms like pain which may precede motor symptoms by more than a decade. The aim of the study was to investigate the effect of Cannabidiol (CBD) and Tetrahydrocannabinol (THC) on Cold Hypersensitivity in reserpine induced Parkinson's disease in mice. Forty-two (42) mice were randomly divided into seven groups of six mice each. All administration we re carried out for three weeks. Cold pain threshold increased significantly (P < 0.05) in reserpine (0.5 mg/kg) + CBD (60 mg/kg) and reserpine (0.5 mg/kg) + THC (6 mg/kg) groups. Malonaldehyde (MDA) concentration decreased significantly in the reserpine (0.5 mg/kg) + CBD (30 mg/kg), reserpine (0.5mg/kg) + THC (4mg/kg) and reserpine (0.5 mg/kg) + CBD (60 mg/kg) +THC (6 mg/kg) treatment groups respectively. Superoxide dismutase (SOD) concentration increased significantly (P < 0.05) in reserpine (0.5 mg/kg) + CBD (60 mg/kg), reserpine (0.5 mg/kg) + THC (6 mg/kg) and reserpine (0.5 mg/kg) + CBD (60 mg/kg) +THC (6 mg/kg). Reduced glutathione level (GSH) increased significantly (p < 0.05) in reserpine (0.5 mg/kg) + THC (6 mg/kg) and reserpine (0.5 mg/kg) + CBD (60 mg/kg) + THC (6 mg/kg) groups. In conclusion, CBD and THC were able to improve cold pain threshold and at the same time decreasing MDA concentration and increasing SOD activity and GSH concentration.
