Göksel Sarohan, Alper Parlakgümüş
Europeanatolia Health Sciences Journal - 2025;3(3):69-75
Introduction: Colorectal signet ring cell carcinoma is a rarely encountered histopathological subtype of colorectal adenocarcinoma and displays unique clinicopathological and prognostic characteristics. Objective: In order to extend the expected survival time and improve the quality of life, this study aimed to determine the factors affecting survival. Method: This retrospective study was directed towards examining the clinicopathological features of colorectal signet ring cell carcinoma and to investigate prognostic factors affecting survival of the patients. Of 2622 patients having colorectal surgery in a state hospital between 1 January 2015 and 1 June 2025, 30 were found to have colorectal signet ring cell carcinoma and included in the study. Kaplan -Meier method was adopted to calculate the rates of cumulative events and Log -rank test was utilized for comparison of survival in terms of prognostic factors. Results: Curative surgery created a significant difference in survival. In fact, the patients undergoing curative surgery had longer survival. However, female gender, T4 invasion depth, N2 -N3 lymph node involvement, presence of metastasis and a stage 3C or higher stage of disease were found to be the factors of poor prognosis. Conclusion: This study has a retrospective design. Therefore, randomized studies are needed to understand the biological behavior of signet ring cell adenocarcinoma and to determine prognostic factors that can affect survival.
