MERVE YİLDİRİM, ELİF AKSAKAL, TAHA YASİN BAYRAM, EDA IRMAK, HARUN GUN, BUNYAMİN OZGERİS, ARZU GORMEZ
The European Chemistry and Biotechnology Journal - 2025;2(1):47-56
Oral infections are a type of infection that occurs in and around the mouth, typically arising when proper oral hygiene is neglected. These infections manifest as symptoms such as mouth sores, dental caries, and periodontal diseases, with dental caries being the most common form. Streptococcus and Lactobacillus bactteria are the primary causative agents in dental caries. These bacteria act as opportunistic pathogens, potentially leading to serious diseases. Moreover, antibiotic resistance is developing in these pathogenic bacteria, limiting treatment options. β-lactam antibiotics are vital due to their broad spectrum and selective toxicity. This study synthesized novel phenethylamine-based β-lactam derivatives, and their antibacterial activities against oral pathogens were investigated. The antibacterial activities of the compounds were determined using agar well diffusion and microdilution assays. The study observed that β-lactam derivatives formed inhibitory zones against the growth of oral pathogens, while imine compounds did not create such zones. The diameter of the inhibition zones for the β-lactam compounds ranged from 0.9 to 2.1 cm. The MIC values were calculated to be between 12.5 and 100 μM. These data suggest that β-lactam derivatives could be potent therapeutic agents for oral infections.
