Shivaraj HIREMATH, Kiran CHOUDHARI, Mallappa SHALAVADI, Shubham TELI
Hacettepe University Journal of the Faculty of Pharmacy - 2026;46(2):112-125
Scirpus kysoor, has been used to treat various illnesses, but its effects on diabetes and cholesterol levels have not been scientifically proven yet. The study investigated the antihyperlipidemic and antidiabetic effects of HESK (hydroethanolic extracts of Scirpus kysoor) in high fat diet (HFD)with streptozotocin induced diabetic rats. Six experimental groups were designated. Group I received 0.9% NaCl, while Groups II-VI were administered HFD (3 ml/kg), Glimepiride (10 mg/kg), or 100, 200, and 400 mg/kg HESK respectively. With the exception of Group I, all rats were fed HFD for 56 days and made diabetic by a single intraperitoneal injection of STZ (35 mg/kg) on day 28. Biochemical markers like Glucose, Cholesterol, Triglycerides, ALP, ALT, AST, HDL, LDL and Total Protein were assessed. Anthropometric parameters, including Body weight, Food intake, AC/TC ratio, abdominal and thoracic circumference were measured. At last of the study, the levels of antioxidant parameters (LPO, CAT, SOD, GSH & total thiols) and the histopathology of the liver and pancreas were evaluated. Results showed HESK significantly reduced glucose, cholesterol, triglycerides, ALP, ALT, AST, and LDL, while increasing HDL and total protein levels (p<0.001) as compared to the control group (HFD). Additionally, antioxidant markers improved, with increased SOD, GSH, catalase, and thiols and decreased LPO(p<0.001)as compared to the control group. Anthropometric parameters such as Body weight, Food intake, Abdominal Circumference (AC), Thoracic circumference (TC) and AC/TC ratio (p<0.001) increased as compared to the control group. Histopathological findings supported these outcomes, confirming HESK's dose-dependent antihyperlipidemic and antidiabetic effects in the diabetic rat model.
