ELİN YULİNAH SUKANDAR, AFRİLLİA NURYANTİ GARMANA, ANGGİ UTRİ AIDASARI, AUDREY AMİRA CRYSTALIA
Journal of Research in Pharmacy - 2019;23(6):1090-1097
Hypertension is an important risk factor of cardiovascular disease which is the leading cause of death. Traditionally, many plants are used to lower blood pressure including Anredera cordifolia (Ten.) v. Steenis and Sonchus arvensis L.. Previous studies found that both plants showed antihypertensive activity through inhibiting angiotensin converting enzyme and inducing diuresis. The aim of this study is to evaluate the antihypertensive effect of Anredera cordifolia (Ten.) v. Steenis leaves extract (ACLE) and Sonchus arvensis L. leaves extract (SALE) combination on hypertensive animal induced with angiotensin II. In this study, blood pressure measurement was done using CODA® tail-cuff blood pressure system plethysmograph. After initial measurement of blood pressure, extracts were administered orally according to the respective groups as follow: ACLE 50, ACLE 100, SALE 50, SALE 100, ACLE-SALE 25-25, and ACLESALE 50-50 mg/kg bw. After 1 hour, angiotensin II 100 μg/kg bw was administered then the blood pressure was re-measured. ACLE 50 and ACLE-SALE 25-25 mg/kg bw were able to significantly lower blood pressure compared to positive control group (p<0.05), while SALE 50 mg/kg bw was not. Significant prevention of blood pressure elevation was seen in ACLE-SALE 25-25 mg/kg bw group with percent inhibition of 54.77% for systole and 67.6% diastole. ACLE 50 and ACLE-SALE 25-25 mg/kg bw were able to reduce the effect of angiotensin II and possibly act as angiotensin receptor antagonist. Furthermore, in extract combination, SALE of 25 mg/kg bw could reduce the dose of single ACLE as antihypertension by half the individual dose.
