G M MOHANA RAO, VENKATESWARARAO, A K S RAWAT, P PUSHPANGADAN, A SHİRWAİKAR
Acta Pharmaceutica Sciencia - 2005;47(1):73-78
The Antioxidant and antihepatotoxic activities of 50% aqueous ethanolic extract of Hemidesmus indicus R, Br. roots were assessed in experimental animals. In carbontetrachloride induced hepatic challenge in rats, a remarkable elevation of lipid peroxidation and a decrease in liver antioxidant enzymes levels were observed. Pretreatment with the 50% aqueous ethanol extract of Hemidesmus indicus R. Br. roots inhibited these alterations. Based on these results we can suggest that in the liver protective and antioxidative effects of H. indicus, possibly involve mechanisms related to free radical scavenging effects.
