Tansu ERKAN, Ayhan ŞENKARDEŞLER, Turgut TAŞKIN, Özlem BİNGÖL ÖZAKPINAR, Ayşe Seher BIRTEKSÖZ TAN, Fatma Betül ZENGİN, Leyla BİTİŞ
Journal of Research in Pharmacy - 2026;30(2):576-582
In this study, antioxidant, antimicrobial, antiproliferative and, cytotoxic activities of the lichen species Ramalina fastigiata, Xanthoria parietina and Aspicilia intermutans were investigated. It was determined that Aspicilia intermutans contained higher DPPH radical and ABTS cation radical scavenging activity and total phenolic substance than the other species. It was determined that Ramalina fastigiata had the highest iron (III) ion reducing antioxidant capacity. It was exhibited that Ramalina fastigiata showed antibacterial activity against Staphylococcus epidermidis (MIC: 312 mug/mL) and Escherichia coli (MIC: 156 mug/mL) strains. In addition, it was determined that Xanthoria parietina showed significant antiproliferative activity on the HeLa cell line. According to the obtained findings, it was determined that none of the three species showed significant toxicity on non-tumoregenic cells. The fact that none of the three species showed toxicity on healthy cell lines suggests that these species can be used for medical purposes.
