Pinar ATLA, Heves KIRMIZIBEKMEZ, Gulcan SEYMEN, Fatma DURSUN
İstanbul Kuzey Klinikleri Dergisi - 2026;13(1):45-50
OBJECTIVE: Clinical observations show that the development of puberty occurs earlier, and the course is accelerated in children born small for gestational age (SGA) compared to peers born average for gestational age (AGA). The aim of this study was to investigate the response to GnRH analogue (GnRAa) treatment in SGA and AGA girls with central precocious puberty (CPP). METHODS: This study included 16 SGA and 137 AGA girls who were receiving GnRHa treatment due to onset of central puberty before the age of eight. SGA group included girls who exhibited normal growth and did not receive growth hormone GH treatment. The response to treatment parameters were compared at the 12th month and at the end of the treatment. RESULTS: The mean age at the onset of puberty, anthropometric data, bone age, difference between bone age and decimal age were not different between SGA and AGA groups, as well as baseline luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol, stimulated LH and LH/FSH ratio. Height SDS, BMI SDS, and predicted adult height at presentation, at 12th month and at the end of the treatment were not different in SGA girls. A significant difference was detected only in BMI parameter which increased in 12th month in AGA girls. CONCLUSION: The findings of our study indicate that SGA girls with precocious puberty who have achieved growth catch-up and lack additional risk factors require a similar approach to AGA girls when initiating and modifying treatment during the follow-up period.
