Fırat CANLIKARAKAYA, Serhat OCAKLI, İbrahim DOĞAN, Bedri Burak SUCU
Archives of Current Medical Research - 2026;7(1):81-90
Background: Acute pancreatitis (AP) is a disease characterized by acute inflammation of the pancreas and histological destruction of acinar cells, most commonly caused by gallstones or excessive alcohol use. In most patients, the disease is mild, but in approximately 20-30% of cases, it presents in a severe form, which can be life-threatening. The severity of acute pancreatitis is classified as mild, moderate, or severe according to the 2012 revision of the Atlanta classification. Early diagnosis of severe acute pancreatitis (SAP) and identification of patients at high risk for complications are crucial for effective treatment. Several inflammation-based scores, including HALP, CAR, SII, PIV, and SIRI, are used to predict the severity of pancreatitis by evaluating inflammation and nutritional status. The aim of this study is to assess the effectiveness of these inflammation indices in predicting the severity of acute pancreatitis in a group of patients. Methods: This is a single-center, retrospective study including 213 patients diagnosed with AP. Patients were classified into two groups based on the revised Atlanta criteria: mild acute pancreatitis (MAP) and moderate/severe acute pancreatitis (SAP). The relationship between the severity of AP and various inflammation-based scores (HALP, CAR, SII, PIV, SIRI) were analyzed. Results: The study included 213 patients. According to the revised Atlanta criteria, 82.6% of patients were diagnosed with mild pancreatitis, 15.5% with moderate pancreatitis, and 1.9% with severe pancreatitis. The HALP score, CAR, PIV, SII and SIRI scores did not show significant differences between the two groups. ROC analysis revealed that these laboratory results and inflammation scores were not significant in predicting the severity of pancreatitis. Conclusion: This study found no significant association between HALP, CAR, SII, SIRI, or PIV scores and acute pancreatitis severity, contrary to previous research. Larger studies are needed.
