BURCU KÖK KENDİRLİOĞLU, AYSE ECE BUYUKSANDALYACİ TUNC, HİDAYET ECE ARAT CELİK, ESMA COREKLİ KAYMAKCI, ELİF SUDE ERTURAN, ŞEVİN DEMİR, SUAT KUCUKGONCU
Southern Clinics of Istanbul Eurasia - 2023;34(4):335-341
INTRODUCTION: There is strong evidence that excess and early cardiovascular disease (CVD) occurs in patients with unipolar depression (UD) and bipolar disorder - depressive episode (BD-d). The aim of this study is to evaluate plasma atherogenic index (AIP), atherogenic coefficient (AC), Castelli risk index I-II (CRI-I and II) and high-density lipoprotein (HDL) related ratios in UD, BD-d and HC. METHODS: The present study was designed as a retrospective and observational study. This study included 128 patients with UD, 184 individuals as a healthy control group and 34 patients with BD-d. AIP [log (TG/HDL)], AC [(TC-HDL)/HDL], CRI-I (TC/HDL) and II (LDL/HDL), MHR (monocyte/HDL), NHR (neutrophil/HDL), PHR (platelet/HDL) and LHR (lymphocyte/HDL) were calculated in these three groups. ANCOVA was used for age- and sex- adjusted means. Results: There were significant differences in fasting glucose (FG) (p=0.016), LDL (p=0.004), HDL (p<0.001), TG (p<0.001), TC (p=0.01), AIP (p<0.001), NHR (p<0.001), MHR (p=0.007), LHR (p<0.001), PHR (p<0.001) between three groups. All these metabolic parameters were correlated with duration of disorder. DISCUSSION AND CONCLUSION: Along with the care of a depressive episode, the management of abnormal metabolic parameters should be planned during diagnosis, follow-up, and treatment. Assessment of AIP and NHR, especially in chronic and unresponsive processes, may be useful in both disorders. In future studies, it is recommended to conduct large-scale studies that are prospectively designed, that monitor the severity of the disease, and that evaluate the CVD risk parameters and treatment of the participants.
