TALHA SARIGÖZ, DENİZ YAVUZ BASKİRAN
Southern Clinics of Istanbul Eurasia - 2023;34(1):78-84
INTRODUCTION: Hepatic steatosis (HS) is a critical element in evaluation of living liver donor candidates (LLDC). We aimed to find predictors of HS while correlating computed tomography (CT) based attenuation assessments with clinical parameters of LLDC. METHODS: A total of 524 LLDC were included in the study. From those, 227 of them were declined due to HS detected by CT and 297 of them underwent successful donation process. These two groups were evaluated statistically in terms of CT based liver attenuation indices, clinical and laboratory parameters to find predictors of HS. Results: Other than low-density lipoprotein, neutrophil count, neutrophil/lymphocyte ratio, platelet distribution width, platelet count, and alpha fetoprotein, all of the laboratory parameters were different between the groups (p<0.05). The median liver attenuation value in accepted donors was 64 and in declined donors, it was 51 (p<0.001). Body mass index (BMI) had the highest diagnostic accuracy for HS followed by alanine aminotransferase (ALT). The cutoff value for BMI (72% sensitivity) was 26.3 kg/m2 and it was 21 IU/L for ALT (69% sensitivity). DISCUSSION AND CONCLUSION: BMI>26.3 and ALT>21 correlate well with HS and those subjects should be evaluated later if more appropriate donor candidate is present.
