Bestegül ÇORUH AKYOL, Gonca GÜLBAY, Özgür ENGİNYURT
Medical Records - 2026;8(1):1722895-1722895
Aim: There are variable treatment options for venous insufficiency depending on the origin of the various etiologic factors, the location, width, depth and infected area of the ulcer. In this study, we aimed to determine the oxidative stress load and to draw attention to the need for a multidisciplinary approach in the whole process as well as early diagnosis and treatment opportunities. Material and Methods: This comparative observational study to investigate oxidative stress parameters in individuals with and without venous insufficiency. Effects of oxidative stress were investigated by serum 8-hydroxy-2' -deoxyguanosine Assay, Malondialdehit Assay, Total Antioxidant Status and Total Oxidant Status Assay tests using kits based on the enzyme-linked immunosorbent assay principle. Results: A total of 68 individuals participated in the study, comprising 45.6% females and 54.4% males. No statistically significant differences were observed between the groups in terms of 8-hydroxy-2' -deoxyguanosine Assay, Total Oxidant Status Assay, Total Antioxidant Status, and Oxidative Stress Index Assay levels (p = 0.417, p = 0.742, p = 0.210, and p = 0.416, respectively). However, the Malondialdehit Assay level in the patient group (rank mean: 25.70) was significantly lower than that of the control group (rank mean: 38.10) (p = 0.007). Conclusion: There are variations in the literature on oxidative stress markers levels in terms of mechanisms of action and outcomes. The varied results in the literature on oxidant and antioxidant mechanisms indicate that studies with much larger samples and analyses should be conducted on this subject.
