Aksanur Gökçe, Esra Topçu, Neşe Yakşi
International Journal of Traditional and Complementary Medicine Research - 2026;7(1):19-26
Aim: It is known that poor sleep quality increases the likelihood of developing a wide range of chronic diseases. Furthermore, it is also known to lead to increased healthcare costs and reduced workforce productivity. The aim of this study is twofold: firstly, to investigate the effect of systemic ozone therapy on subjective sleep quality; secondly, to evaluate its safety profile. Material and Methods: This prospective, single-centre study comprised 51 patients (31 females, 20 males; mean age = 51.05 +/- 11.85 years) receiving routine systemic ozone therapy -administered rectally -at an outpatient clinic specialising in Traditional and Complementary Medicine (TCM). The Pittsburgh Sleep Quality Index (PSQI) was utilised to assess sleep quality prior to and following a standardised 8-week ozone therapy protocol comprising 10 sessions. Results: PSQI scores were associated with significant improvements after treatment (mean change -2.72 +/- 3.21; p < 0.001) and approached thresholds considered clinically significant in previous sleep research. GLMM analyses revealed significant main effects of time, age, gender, education, income, and comorbid health conditions on PSQI outcomes (all p < 0.05). No serious adverse events were observed throughout the study period. Conclusion: The current study demonstrated that systemic ozone therapy was associated with a significant improvement in subjective sleep quality, exhibiting a positive safety profile, albeit with a small pilot group and short follow-up period. These findings suggest that ozone therapy may be a promising complementary approach for managing sleep disorders, particularly in older adults and individuals with comorbid conditions. These findings are exploratory and preliminary.
