Orhan ASLAN, Mustafa ŞAHİN, Ramazan TOPCU, Mahmut Arif YÜKSEK, İsmail SEZİKLİ, Aşkın Kadir PERÇEM, Havva Hande Keser ŞAHİN, Bayram YILMAZ, Emin RENÇBER
Journal of Health Sciences and Medicine - 2026;9(3):658-663
Aims: Acute appendicitis (AA) is a common surgical emergency with a heterogeneous clinical and pathological spectrum. Given their established roles in immune modulation, inflammation, and host-pathogen interactions, ABO blood group antigens have been investigated in various infectious and inflammatory diseases. In this study, we aimed to investigate the association between blood groups and the clinical course of acute appendicitis. Methods: This retrospective study data from patients who underwent appendectomy at our center were analyzed. Patients were classified into normal (n=42), uncomplicated (n=970), and complicated (n=213) appendicitis groups based on histopathological findings. Demographic data, ABO blood groups, histopathological findings, preoperative laboratory parameters, and length of hospital stay were evaluated and statistical analyses were performed. Results: No significant differences were observed in ABO blood group distribution among histopathological subgroups (p>0.05). In multivariate analysis, age and C-reactive protein remained independent predictors of complicated appendicitis (p<0.001). Although a lower proportion of blood group O was observed in complicated cases, this trend did not reach statistical significance. Conclusion: ABO blood groups do not appear to be independently associated with severity of acute appendicitis. Future large-scale, multicenter prospective studies incorporating molecular and microbiota-based analyses are warranted to better elucidate individual risk profiles and improve prognostic accuracy in acute appendicitis.
