Neslihan Akanil Fener, Aysu Sinem Koç, Ekrem Cengiz Seyhan
Journal of Current Hematology & Oncology Research - 2025;3(4):77-81
Aims : Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent head and neck cancers, characterized by declining survival rates. Understanding prognostic factors is essential for improving patient outcomes, particularly in the context of angiogenesis. This study was designed to comprehensively evaluate the expression of endoglin (CD105) as a marker of angiogenesis in LSCC and to determine its potential association with microvascular density (MVD) and other histopathological parameters. Methods : Forty-two previously untreated patients who underwent laryngectomy and neck dissection were retrospectively included in the current analysis. Regions of highest vascularization ("hot spots") were delineated, and MVD was assessed using CD105 immunostaining. Results : Findings from this study reinforce the hypothesis that MVD might not constitute a reliable prognostic biomarker in LSCC, highlighting the complex and multifactorial nature of tumor angiogenesis. Conclusion : MVD has been reported as an independent prognostic indicator in various malignancies; however, evidence regarding CD105 expression in LSCC remains extremely limited. Previous studies have yielded conflicting results concerning the prognostic significance of MVD in head and neck SCCs, underscoring the complexity of tumor biology. This study adds to the existing discourse, attributing discrepancies to the absence of tumor-specific markers, intratumoral heterogeneity, and methodological variations.
