CAN ÖZKAN, YÜCEL KANAL
Annals of Clinical and Analytical Medicine - 2024;15(11):789-793
Aim: This retrospective observational study aimed to investigate the relationship between the Naples prognostic score (NS) and SYNTAX score (SS) in patients diagnosed with non-ST segment elevation myocardial infarction (NSTEMI), focusing on their implications for coronary artery disease (CAD) severity. Material and methods: Data were collected from 300 consecutive NSTEMI patients who underwent coronary angiography between January 2024 and May 2024. NS, calculated from serum albumin, total cholesterol, neutrophil/lymphocyte ratio (NLR), and lymphocyte/monocyte ratio (LMR), was assessed alongside SS, which quantifies CAD complexity based on angiographic findings. Results: NS was significantly higher in patients with more extensive CAD, as indicated by higher SS (p < 0.05). This association underscores NS as a potential marker for predicting CAD severity in NSTEMI patients. Age was also noted to correlate significantly with higher NS, consistent with literature linking age to poorer nutritional status and cardiovascular outcomes. Discussion: The findings of this study underscore the potential clinical relevance of the NS in patients with NSTEMI. NS, which integrates serum albumin levels, serum cholesterol levels, NLR, and LMR, emerged as significantly associated with the SS, a marker of CAD complexity. The study revealed that higher NS correlated with increased SS, suggesting that patients with poorer nutritional and inflammatory profiles may exhibit more extensive CAD. This association implies that NS could serve as a useful tool in risk stratification and management decisions for NSTEMI patients undergoing coronary angiography. Moreover, the study highlighted age and lipid profiles (triglycerides and LDL) as independent predictors of NS, further emphasizing the multifactorial nature of cardiovascular risk assessment in these patients.
