Nazife Nur ÖZER ŞENSOY, Sevil SADRİ, Yavuz AYAR, Türker EMRE, Özgür Ömer GÜL, Elif ARDIÇ, Nimet AKTAŞ, Hatice ORTAÇ, Mehmet USTA
The European Research Journal - 2026;12(9):1065-1079
Objective: The hemoglobin-albumin-lymphocyte-platelet (HALP) score reflects nutritional-inflammatory status and is a prognostic marker in several malignancies. Its potential association with renal recovery in newly diagnosed multiple myeloma (MM) remains unclear. We investigated the relationship between baseline HALP score and renal recovery in patients with newly diagnosed MM. Methods: We retrospectively evaluated 133 consecutive patients with newly diagnosed MM. Renal response analyses were restricted to 56 patients meeting prespecified baseline eGFR criteria. Renal recovery was defined by modified International Myeloma Working Group (IMWG) criteria using the last available follow-up eGFR. The median follow-up was 15 months (interquartile range [IQR], 6.5-20.75). The HALP score was evaluated using group comparisons, receiver operating characteristic (ROC), correlation, and logistic regression analyses. Results: In the renal outcome cohort (n = 56), 37 (66.1%) achieved renal recovery and 19 (33.9%) experienced nonrecovery. The median HALP score did not differ significantly between the recovery and nonrecovery groups (27.66 [IQR, 20.85-45.95] vs 22.82 [IQR, 9.90-54.94]; P = .364). HALP score discrimination for renal recovery was limited (area under the curve [AUC], 0.575; 95% CI, 0.435-0.706; P = .422). An exploratory cutoff of >18.91 yielded a sensitivity of 81.1% and specificity of 47.4%. HALP >=18.91 was not significantly associated with renal recovery in univariable analysis (odds ratio [OR], 3.12; 95% CI, 0.91-10.64; P = .069) but showed a significant association after multivariable adjustment (OR, 4.32; 95% CI, 1.13-16.58; P = .033). The HALP score did not correlate with DeltaeGFR (r = -0.058; P = .671). Conclusions: The continuous HALP score showed limited discrimination for renal recovery. However, an exploratory threshold of >=18.91 was associated with recovery after multivariable adjustment. Given the modest sample size, wide CI, and nonsignificant ROC analysis, this threshold-based finding requires confirmation in larger independent cohorts.
