Kemal Ozan LÜLE, Soner BERŞE, Anıl BEYAZ
The European Research Journal - 2026;12(8):847-856
Objective: This study aimed to examine the association between type 2 diabetes mellitus (T2DM) and metabolic profile alterations-particularly dyslipidemia-in patients with hypertension, and to determine whether T2DM is independently associated with dyslipidemia in this population. Methods: This retrospective cross-sectional study included 191 patients with a documented diagnosis of hypertension followed between September 1, 2024, and September 1, 2025. Participants were categorized according to T2DM status. Demographic, clinical, and laboratory data were retrieved from electronic medical records. Continuous variables are expressed as median (interquartile range) and categorical variables as counts and percentages. Group comparisons were performed using the Mann-Whitney U and chi-square tests. Associations between variables were evaluated using Spearman's rank correlation analysis, and factors independently associated with dyslipidemia were identified using binary logistic regression analysis. Results: Participants had a median age of 50.0 (42.0-58.0) years; 66.0% were female and 24.1% had T2DM. Triglyceride levels were significantly higher in the T2DM group (P=0.039), as were C-reactive protein concentrations (P=0.025). Dyslipidemia was present in 56.5% of patients with T2DM compared with 13.8% of those without (P<0.001). In multivariable analysis, T2DM remained independently associated with dyslipidemia (odds ratio=4.47, 95% confidence interval: 1.58-12.67; P=0.005), as did age (odds ratio=1.038; P=0.049). Conclusion: T2DM in hypertensive individuals was significantly and independently associated with dyslipidemia, most prominently reflected by elevated triglyceride levels. Lipid screening and cardiometabolic risk management should be approached more comprehensively in hypertensive patients with T2DM.
