Funda YILDIRIM BORAZAN, Çağatay ÇAVUŞOĞLU, İbrahim İLERİ, Berna GÖKER
European Journal of Geriatrics and Gerontology - 2026;8(1):50-55
Objective: Serum uric acid (SUA) is a marker with both antioxidant and prooxidant properties. While abnormal SUA levels have been linked to adverse outcomes, the effects of long-term intra-individual SUA fluctuations, particularly in older adults, remain unclear. This study examined the relationship between SUA variability and various components of the comprehensive geriatric assessment (CGA), including functional status, cognition, nutrition, and mood. Materials and Methods: The study population consisted of 102 patients aged 65 years and older who were evaluated in a geriatric outpatient clinic. Uric acid coefficient of variation (SUA-CV) was calculated using four SUA measurements over a 12-year period. Participants were classified into low and high SUA-CV groups. All participants underwent CGA. Results: Higher SUA-CV was significantly associated with lower activities of daily living, instrumental activities of daily living, mini-mental state examination, and mini nutritional assessment-short form scores, and with higher GDS scores, polypharmacy, and comorbidities (p < 0.05). Correlation analysis revealed significant associations between SUA-CV and various CGA parameters, particularly those reflecting functional and nutritional decline. Conclusion: Increased variability in SUA levels is associated with poor functional, cognitive, nutritional, and mood status in older adults. SUA-CV may be a novel and cost-effective biomarker for systemic vulnerability in aging and may help guide individualized geriatric care.
