Nihat Söylemez, Burak Toprak, Rıdvan Bora, Abdulkadir Bilgiç, Özkan Karaca
Journal of Cardio-Vascular-Thoracic Anaesthesia and Intensive Care Society - 2025;31(4):135-142
Objectives: To investigate the relationship between the SYNTAX score and inflammatory markers (CRP , RDW, PDW) in patients undergoing coronary artery bypass grafting (CABG) and to evaluate their independent predictive roles in in-hospital mortality. Methods: This retrospective, single-center study included 160 consecutive patients who underwent elective isolated CABG between January 2024 and April 2025. Preoperative SYNTAX scores were calculated, and inflammatory markers (CRP , RDW, PDW) were measured within 24 hours before surgery. The primary endpoint was in-hospital mortality. Correlation analyses, subgroup comparisons, and multivariate logistic regression were performed. Results: CRP , RDW, and PDW levels significantly increased across higher SYNTAX categories. Positive correlations were observed between SYNTAX and CRP (rho=0.27, p=0.003), RDW (rho=0.24, p=0.006), and PDW (rho=0.22, p=0.010). Multivariate logistic regression analysis demonstrated that SYNTAX (OR=1.12, p=0.014), CRP (OR=1.06, p=0.021), RDW (OR=1.09, p = 0.029), and PDW (OR=1.18, p=0.028) were independent predictors of in-hospital mortality. The combined model yielded the highest discriminative performance (AUC=0.88) compared with the SYNTAX score alone (AUC=0.71). Conclusion: The combined evaluation of the SYNTAX score with inflammatory markers (CRP , RDW, PDW) provides complementary prognostic value and significantly improves the prediction of in-hospital mortality in CABG patients. This integrated approach may enhance preoperative risk stratification and aid in the early identification of high-risk individuals.
