Gouri Chandrapalsing Rajput, Rachana Anil Sontakke, Divya Aggrawal, Girish Nanoti
The Journal of Pediatric Research - 2025;12(3):161-164
There is very little information on the global occurrence and clinical features of acute soft head syndrome, as it is an incredibly rare condition. Subgaleal hematoma (SGH) represents an uncommon, yet significant complication in adolescents with sickle cell anaemia (SCA). Here, we present a case of a 16-year-old with sickle cell disease who developed a spontaneous SGH. This report highlights the diagnostic challenges and management strategies associated with this rare occurrence and reviews recent literature in order to enhance understanding of SGH within the context of SCA.