TUNA ALBAYRAK, BEYZA YÜKSEL
Ankara Üniversitesi Tıp Fakültesi Mecmuası - 2024;77(1):101-106
Objectives: Renal failure is linked to both acute and chronic inflammatory processes for a number of reasons, particularly in end-stage renal disease. Although it has demonstrated potential as an inflammatory marker in a number of diseases, the fibrinogen-to-albumin ratio’s (FAR) predictive significance in critically ill dialysis patients is yet unknown. The purpose of this study was to look into FAR as a possible mortality predictive indicator in this particular patient population. Materials and Methods: A retrospective analysis of 226 patients admitted to the intensive care units of internal medicine and anesthesia, undergoing dialysis between 12.12.2021 and 15.12.2023, was conducted. Inclusion criteria were age ≥18, diagnosis of albumin or kidney disease, and availability of complete clinical and laboratory data. Exclusion criteria included anemia unrelated to kidney disease and inability to access relevant data. Demographic, clinical, and laboratory variables were collected, and statistical analyses were performed. Results: The study revealed significant associations between mortality and lower body mass index, higher APACHE II score, elevated creatinine levels, lower glomerular filtration rate, higher albumin levels, and increased FAR. With an 81.75% sensitivity, 39.00% specificity, 62.80% positive predictive value, and 62.90% negative predictive value, the FAR cut-off point for mortality was found to be 241. Area under the curve of 58.1% was shown by receiver operating characteristic analysis. Conclusion: FAR shows promise as a prognostic indicator for mortality in intensive care dialysis patients. While further prospective and multicenter studies are needed to validate its clinical usability, FAR could contribute to enhanced prognostic assessments and improved patient care in this specific population.
