SEVAL YILMAZ ERGANİ TOLGAY TUYAN İLHAN BETÜL TOKGÖZ BURAK BAYRAKTAR MEVLÜT BUCAK MÜJDE CAN İBANOĞLU KADRİYE YAKUT YÜCEL KADRİYE ERDOĞAN CANTEKİN İSKENDER YAPRAK ÜSTÜN
Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi - 2023;56(2):117-120
AIM: We investigated whether measurement of triglyceride/glucose index (TyG) and triglyceride/HDL-cholesterol ratio (TG /HDL-c) in the first trimester can predict gestational diabetes mellitus (GDM). MATERIAL AND METHOD: Twenty-five patients with GDM and 52 women without GDM with normal glycemic control during pregnancy were included in the study as a control group. Both insulin-controlled diabetes and diet-controlled diabetes were included in the diagnosis of GDM. Fasting glucose and plasma lipid profiles including TG, HDL-c, TyG index, and TG /HDL-c measured in the first trimester were analyzed. RESULTS: Triglyceride values (mean 133±40 mg/dL in the gestational diabetes group, 100±54 mg/dL in the control group), TyG index (15.0±8.9 in the mean gestational diabetes group, 8.8±5.0 in the control group), and TG/HDL-C ratio (mean 3.3±2.6 in the gestational diabetes group and 1.9±2.6 in the control group) was found to be significantly higher in the GDM group (p=0.01, p=0.01, p=0.01, respectively). The optimal cutoff value for TyG index was 10.4, sensitivity was 76%, specificity was 77%, and area under the receiver characteristic curve (AUC) was 0.765 to predict GDM (p < 0.001). The optimal cutoff value for the TG /HDL-C ratio was 2.3, sensitivity was 76%, specificity was 69, AUC 0.697 to predict GDM (p=0.005). CONCLUSION: TyG and TG/HDL-C ratio measured in the first trimester are thought to predict GDM better than fasting plasma glucose.
