Yusuf Ahmet ÇETİN, Atıf TEKİN
Turkish Medical Student Journal - 2026;13(2):39-43
Multiple primary malignant neoplasms pose significant challenges in staging and treatment, particularly when they present synchronously with widespread metastatic burden. This report details the rare case of a 67-year-old male with a significant smoking history who was diagnosed with synchronous, advanced-stage malignancies: lung adenocarcinoma and a highly suspicious second primary tumor in the anal canal/rectum. Initial evaluation the lung cancer was Stage IVB with extensive metastases (liver, brain, adrenal, lymph nodes). Crucially, the 18F-fluorodeoxyglucose positron emission tomography/computed tomography indicated a distinct, highly active lesion in the anorectal region, necessitating definitive pathological distinction from metastasis. The management plan initiated palliative radiotherapy for cerebral metastases, reflecting the complexity of treating two concurrent primary cancers.
