MESUT AKARSU, SULEYMAN DOLU, MURAT HARPUTLUOGLU, SEZAİ YİLMAZ, MURAT AKYİLDİZ, GENCO GENCDAL, KAMİL YALCİN POLAT, DİNC DİNCER, HAYDAR ADANİR, ILKER TURAN, FULYA GUNSAR, ZEKİ KARASU, HALE GOKCAN, SEDAT KARADEMİR, GOKHAN KABACAM, MERAL AKDOGAN KAYHAN, MURAT KİYİCİ, MURAT TANER GULSEN, YASEMİN BALABAN, AHMET BULENT DOGRUL, ALİ SENKAYA, ZEYNEP MELEKOGLU ELLİK, FATİH EREN, RAMAZAN IDİLMAN
Hepatology Forum - 2024;5(1):3-6
Background and Aim: This study aimed to identify the indications for liv-er transplantation (LT) based on underlying etiology and to characterize the patients who underwent LT. Material and methods: We conducted a multicenter crosssectional ob-servational study across 11 tertiary centers in Turkiye from 2010 to 2020. The study included 5,080 adult patients. Results: The mean age of patients was 50.3±15.2 years, with a predominance of female patients (70%). Chronic viral hepatitis (46%) was the leading etiological factor, with Hepatitis B virus infection at 35%, followed by cryptogenic cirrhosis (24%), Hepatitis C virus infection (8%), and al-cohol-related liver disease (ALD) (6%). Post-2015, there was a significant increase in both the number of liver transplants and the proportion of living donor liver transplants (p<0.001). A comparative analysis of patient characteristics before and after 2015 showed a significant decline in viral hepatitis-related LT (p<0.001), whereas fatty liver disease-related LT significantly increased (p<0.001). Conclusion: Chronic viral hepatitis continues to be the primary indication for LT in Turkiye. However, the proportions of non-alcoholic fatty liver disease (NAFLD) and ALD-related LT have seen an upward trend over the years.
