YAMİLÉ HEREDIA DÍAZ, JULİO C ESCALONA ARRANZ, ANİA OCHOA PACHECO, ROSALİA GONZÁLEZ FERNÁNDEZ, PEDRO L BATISTA CORBAL, PAUL COS, ALEXANDRA ESCALONA CAPARROS
Acta Pharmaceutica Sciencia - 2023;61(3):269-284
The present research aimed is to carry out the phytochemical analysis and to evaluate the antimicrobial and antioxidant activity, of the lipid phase from Cuban endemic plant Zanthoxylum pistaciifolium Griseb leaves. The total extract was fractioned by Column Chromatography, while its lipid fractions were analyzed by Nuclear Magnetic Resonance and Gas Chromatography-Mass Spectrometry. Antimicrobial activity versus a strain panel of two bacteria and six yeast was tested by microdilution method. Antioxidant activity was evaluated as the scavenging property on DPPH· and ABTS·+ radicals. For the first time 31 compounds are informed, among which fatty acid derivatives and sesquiterpenes prevail. Ethyl palmitate and geranyllinalool emerge as the main compounds. Good anti-Candida activity as well as a moderate radical scavenging property were demonstrated. The cell viability determined reflects a slight toxicity over Vero cells (IC50 in 34.9 ± 0.78 μg/mL). The investigation reveals that lipid phase has an interesting potential for pharmaceutical applications.
