Melike DELİPOYRAZ, Kamuran ULUÇ, Gülçin Hilal ALAY
Cam and Sakura Medical Journal - 2026;6(2):76-78
Acute pancreatitis associated with severe hypertriglyceridemia, especially when it develops in the context of familial hyperlipidemia and chylomicronemia syndrome, is characterized by rapid clinical deterioration, a necrotizing course, and multiple organ dysfunction. Therapeutic plasma exchange (TPE) may be considered a treatment option in severe cases due to its rapid triglyceride (TG)-lowering effect. In our patient, TG levels above 2000 mg/dL, together with necrotizing pancreatitis, metabolic acidosis, and acute kidney injury, indicated rapid clinical deterioration. The observed reduction in TG levels and the clinical improvement in this patient suggest that TPE could be considered in selected severe cases. Early use of TPE in intensive care settings may be an option in selected cases; however, further studies are required.
