İbrahim KILINÇ, Vahit MUTLU, Ömer Bilgehan POYRAZOĞLU, Mahmut Arif YÜKSEK, İsmail Alper TARIM, Alparslan ERTENLİCE, Kadir YILMAZ
Archives of Current Medical Research - 2026;7(3):581-591
Background: This retrospective study aimed to investigate the clinical and therapeutic effects of adjacent organ invasion in gastrointestinal stromal tumor (GIST) cases. Methods: The files of 114 GIST patients from various centers who underwent surgery by the principal investigator be-tween January 2007 and December 2020 were retrospectively included. Patients were divided into two groups: those with adjacent organ invasion (n=29) and those without (n=85). Results: Invasion was significantly correlated with symptoms (r=0.271; p<0.01), location (r=0.274; p<0.01), focus (r=0.277; p<0.01), metastasis history (r=0.277; p<0.01), post operation metastasis (r=0.352; p<0.01), maximum diameter (r=0.311; p<0.01), surgical margin (r=0.311; p<0.01), recurrence (r=0.287; p<0.01), post operation blood transfusion (r=0.263; p<0.01) and NIH (National Institutes of Health) risk class (r=0.460; p<0.01). Effect of invasion (OR=1.863; p<0.01), loca-tion (OR=0.463; p<0.05), focus (OR=3.037; p<0.01), maximum diameter (OR=0.012; p<0.05), surgical margin (OR=1.587; p<0.05), preoperative blood transfusion (OR=2.426; p<0.01), post operation blood transfusion (OR=1.710; p<0.05) and NIH risk class (OR=1.568; p<0.05) were significant at univariate level. However, their effects on complication at multivar-iate level was insignificant (p>0.05). Additionally, exploratory multivariate analysis identified abdominal pain, multiple tumor foci, and high NIH risk class as clinical predictors of adjacent organ invasion itself (p<0.05). Conclusion: Adjacent organ invasion does not appear to be an independent predictor of postoperative complications in GIST patients. However, its association with specific clinical markers warrants consideration for preoperative risk assess-ment and surgical planning. Therefore, more prospective studies with more variables are needed to better understand the impact of invasion on postoperative complications in GIST cases.
