Abdulcebbar ŞİPAL, Aziz İnan CELİK, Tahir BEZGİN, Burcu KODAL, Mujdat AKTAS, Yunus KOC, Sadiye Nur DALGIC, Metin ÇAĞDAŞ, Tumer Erdem GULER, Yalçın DALGIÇ, Samet SOLMAZ, Ahmet Berk DUMAN
Eastern Journal of Medicine (EJM) - 2026;31(4):660-666
Coronary artery ectasia (CAE) is an abnormal dilatation of coronary arteries associated with ischemic complications and thrombotic events. Systemic inflammation and impaired nutritional status are believed to play a pivotal role in its pathogenesis. The Naples Prognostic Score (NPS), a composite marker of inflammation and nutrition, has been associated with adverse cardiovascular outcomes. This study aimed to evaluate the relationship between NPS and the presence of CAE. We retrospectively analyzed 139 patients who underwent coronary angiography between May 2023 and February 2026. Patients were classified into CAE (n=26) and control (n=113) groups. NPS was calculated based on serum albumin, total cholesterol, neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR). Univariable and multiple logistic regression analyses were performed to identify predictors of CAE. Receiver operating characteristic (ROC) analysis assessed the discriminatory ability of NPS. Patients with CAE exhibited significantly higher NPS values compared to controls (2.15 +/- 1.4 vs. 1.42 +/- 0.9; p=0.025). Multiple analysis demonstrated that NPS was an independent predictor of CAE (OR: 2.018, 95% CI: 1.301-3.129, p=0.002). ROC analysis revealed good discriminatory performance for NPS (AUC: 0.759, p<0.001). Higher NPS values are independently associated with the presence of CAE. NPS may serve as a simple, accessible biomarker reflecting systemic inflammation and malnutrition, providing additional risk stratification in patients undergoing coronary evaluation.
