Arzu GUNTURK, Muzeyyen ERYILMAZ
The Medical Bulletin of Haseki - 2026;64(3):186-191
Aim: Systemic immune-inflammatory indices have recently been investigated as potential biomarkers in several inflammatory and autoimmune diseases. This study aimed to investigate the symptom-based diagnostic value of the systemic immuno-inflammatory index (SII) and the systemic immunoresponsive index (SIRI) in patients with Hashimoto's thyroiditis (HT). Methods: The medical records of 169 patients who presented to our clinic between January 2023 and June 2023 were retrospectively reviewed. Demographic and laboratory parameters including age, gender, drug use, thyroid-stimulating hormone (TSH), anti-thyroid peroxidase antibody (Anti-TPO), Anti-Tg, platelet (PLT), neutrophil, lymphocyte, monocyte, SIRI, and SII values were analyzed. SII and SIRI indices were calculated using standard formulas based on complete blood count parameters. The association between inflammatory indices and symptom status was evaluated using correlation and logistic regression analyses. Results: Spearman's rho correlation analysis showed that the correlation between symptom positivity and Anti-TPO was significant (r=0.203; p<0.01). The correlation of symptom positivity with age, gender, drug usage, TSH, anti-Tg, PLT , neutrophil, lymphocyte, monocyte, SIRI, and SII was not statistically significant. Binary logistic regression analysis showed that the effects of gender, drug usage, age, SIRI, and SII on symptom positivity were not statistically significant. Although the effects of SIRI and SII on symptom positivity were not significant, the effect of Anti-TPO was significant (B=0.002; p<0.01). Conclusion: Neither SIRI nor SII had diagnostic value in patients with HT based on symptoms. Therefore, clinical evaluations based on the SIRI and SII indicators for monitoring disease progression and morbidity in cases of HT may not provide reliable information for symptom-based clinical evaluation.
