RUKİYE ARİKAN, TUGBA AKİN TELLİ, OZKAN ALAN, NAZİM CAN DEMİRCAN, TUGBA BASOGLU, OZLEM ERCELEP, HANDAN KAYA, ONUR BUGDAYCİ, UMİT UGURLU, ZERRİN OZGEN, FAYSAL DANE, PERRAN FULDEN YUMUK
Eurasian Journal of Medical Investigation - 2021;5(1):148-152
Objectives: The objective of the study was to evaluate clinicopathologic and radiologic features of patients with pleomorphic lobular breast cancer (pleomorphic lobular carcinoma [PLC]). Methods: We retrospectively evaluated the clinicopathologic and radiologic features of 25 PLC patients treated in our division from 2012 to 2018. Results: Median age was 50 (range, 4255) and 48% were postmenopausal. The presence of spiculated mass was 92%. Median tumor size was 21.9 mm (SD±12.7 mm) and axillary lymph node positivity was 44%. Frequency of microcalcification was 12% and frequency of occult breast cancer was 8%. About 72% of patients had Stage 2 or 3 disease. De novo metastatic disease was 8% and another 8% developed metastasis during follow-up. ER, PR, and Her2/neu were positive in 76%, 44%, and 8%, respectively, and 16% of patients were triple negative. All tumors were Grade III. Median Ki-67 was 22% (range 390%). Frequency of lymphovascular invasion was 52%. Patients were followed median of 34.5 months (95% CI, 22.246.8), since during this period, two patients recurred and five died, median disease-free survival and overall survival could not be reached. Conclusion: Our data suggest that patients with PLC present with poor prognostic features such as large tumor size, axillary lymph node positivity, and high lymphovascular invasion and tumor grade and Ki-67.
