BELGİN DEVRANOGLU, CİGDEM YAYLA ABIDE, ENİS OZKAYA, TAYLAN SENOL, TAYFUN KUTLU, SEMRA KAYATAS ESER
Gynecology Obstetrics & Reproductive Medicine - 2018;24(2):76-81
OBJECTIVES: The aim of this study was to assess the predictive value of coagulation tests at trigger day in patients with isolated factor V Leiden mutation who underwent intracytoplasmic sperm injection cycle. STUDY DESIGN: Ninety women with isolated factor V Leiden mutation underwent intracytoplasmic sperm injection cycles with an indication of unexplained infertility. In all participant’s antagonist protocol was used for ovarian hyperstimulation and coagulation tests including activated partial thromboplastin time, partial thromboplastin time, international normalized ratio, serum fibrinogen and D-dimer levels at trigger day were determined to predict successful implantation. All the clinical parameters specific for the treatment and some patient characteristics were recorded for each participant. RESULTS: There was no significant difference between groups with and without successful implantation in terms of age, body mass index, basal hormone levels (follicle stimulating hormone, estradiol, progesterone at day 3 and antimullerian hormone) (p>0.05). Estradiol and progesterone levels at trigger day were comparable between groups (p>0.05). Groups had similar endometrial thickness at embryo transfer day (p>0.05). Some ovarian stimulation characteristics including initial gonadotropin dose, number of follicles >17 mm, number of oocytes harvested and number of embryos were similar between groups (p>0.05). Although there was no significant difference between groups with regard to activated partial thromboplastin time and partial thromboplastin time levels, international normalized ratio level were significantly lower while D-dimer levels and fibrinogen were significantly higher in cases without implantation (p<0.05). CONCLUSION: D-dimer, fibrinogen and international normalized ratio levels were significant predictors for successful implantation in women with isolated factor V Leiden who underwent ovulation hyperstimulation.
