RAJEEV SHARMA, MANUEL GONZALEZ, VİSHY CHAUDHARY, DAPHNE VİLLANUEVA, CHAVONNE NEWMAN, JESSİE DANFORTH, MD SHAHRİER AMİN
Experimental and Clinical Transplantation - 2024;22(5):392-395
We present a challenging clinical case of a 68-year-old female kidney transplant recipient who had a complicated posttransplant course marked by borderline T-cell-mediated rejection and BK virus nephropathy. The treatment for borderline rejection with steroids resulted in overimmunosuppression, and the patient acquired cytomegalovirus infection manifesting as colitis and SARS-CoV-2 infection. This progressed rapidly to collapsing glomerulopathy and allograft failure. This study also highlights the challenges in surveillance with donor-derived cell-free DNA in the setting of allograft injury by multiple viral infections.
