Uğur Serkan ÇİTİLCİOĞLU, Harun ÖZMEN, Bahar AYDINLI, Didem DERİCİ
Çukurova Anestezi ve Cerrahi Bilimler Dergisi - 2026;9(2):235-240
Aim: To compare the effects of proton pump inhibitors (PPIs) and histamine -2 receptor blockers (H ?RBs) on renal function in critically ill adults with preserved baseline kidney function. Methods: This retrospective cohort study included 210 intensive care unit (ICU) patients (105 PPIs, 105 H ?RBs) hospitalized for at least 15 days at Mersin City Training and Research Hospital. Serum creatinine and estimated glomerular filtration rate (eGFR) were recorded on ICU days 0, 5, 10, and 15. Acute kidney injury (AKI) was defined according to the kidney disease : Improving Global Outcomes (KDIGO) criteria. Group comparisons were performed using appropriate parametric and non -parametric tests. A sensitivity analysis was conducted after excluding pa -tients exposed to sepsis, vasopressors, contrast, or nephrotoxic drugs. Results: Baseline demographics, illness severity, and potential confounders were comparable between groups. The incidence of AKI was similar in the PPI and H ?RB groups (12.4% vs 13.3%, p = 0.81). Serial eGFR measurements followed parallel patterns, showing an early decline and partial recovery by day 15 (p > 0.05 for all time points). Results remained consistent after sensitivity analysis. Conclusion: Short -term PPI therapy did not increase AKI risk or impair renal function compared with H ?RB use. PPI administration limited to the acute ICU phase appears safe regarding renal outcomes; however, unnecessary or prolonged administration should be avoided in accordance with current stewardship recommendations.
