Uğur Fahri Yürekli, Mehmet Yürekli, Ahmet Kaya
The Ulutas Medical Journal - 2025;11(4):74-79
Background: One of the key mechanisms affecting mortality and morbidity in intensive care unit (ICU) patients is oxidative stress and the accompanying antioxidant defense system. The Platelet Mass Index (PMI) has been proposed as a novel parameter associated with both disease severity and inflammation. This study sought to explore the association between platelet mass index (PMI) and the levels of total oxidant status (TOS), total antioxidant status (TAS) , and oxidative stress index (OSI) in patients admitted to the intensive care unit. Methods : This prospective study included 152 ICU-hospitalized patients and 60 healthy controls . Blood samples were analyzed to determine TOS, TAS, procalcitonin (PCT), ferritin, C -reactive protein (CRP), mean platelet volume (MPV), white blood cell count, and platelet count (PLT). Platelet mass index (PMI) was calculated using PLT and MPV values, while OSI was calculated using TOS and TAS results. Results: Among ICU patients, PMI, CRP, TOS, and OSI levels were elevated, whereas PLT and TAS levels were reduced compared with the control group. No significant clinical correlation was observed between PMI and the other measured variables. Conclusion : PMI may serve as a simple , readily calculable biomarker reflecting oxidative stress levels in ICU patients. PMI can serve as a supportive parameter for evaluating oxidative stress in intensive care practice.
