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CONCOMITANT MITOCHONDRIAL DIABETES AND MYOPATHY MISTOOK FOR COMPLICATIONS OF IMMUNOSUPPRESSANTS AFTER KIDNEY TRANSPLANT

YONG HOON SHİN, AE JİN KİM, HAN RO, JAE HYUN CHANG, Jİ YONG JUNG, WOO KYUNG CHUNG, HYUN HEE LEE

Experimental and Clinical Transplantation - 2021;19(7):736-738

Department of Internal Medicine, College of Medicine, Gachon University, Incheon, Korea

 

Posttransplant diabetes mellitus, presenile deafness, and myopathy are not commonly accompanied symptoms after kidney transplant. We report the case of a 48 year old woman with diabetes mellitus, sensorineural hearing loss, and severe myopathy without neuropathy after deceased donor kidney transplant. She had a mitochondrial DNA point mutation at position 3243 (A>G), and mitochondrial diseases such as maternally inherited diabetes deafness or mitochondrial encephalomyopathy, lactic acidosis, and stroke like episodes were suspected. Diabetes and other symptoms following kidney transplant can often be overlooked as complications of immunosuppressants taken after kidney transplant. However, in patients without a known cause of their symptoms, appropriate examinations and consultation for other diseases, including genetic diseases, should be considered.